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Corticosteroids may increase the risks related to infections with any pathogen, including viral, bacterial, fungal, protozoan, or helminth infection. Corticosteroids may also mask some signs of current infection. Avoid the use of prednisolone in patients with a fungal infection or bacterial infection that is not adequately controlled with anti-infective agents. Activation of latent disease or exacerbation of intercurrent infection due to pathogens such as Amoeba, Candida, Cryptococcus, Mycobacterium, Nocardia, Pneumocystis, or Toxoplasma can occur in patients receiving systemic corticosteroids. Rule out infection with latent or active amebiasis before initiating corticosteroid therapy in patients who have spent time in the tropics or who have unexplained diarrhea.
Recovery of HPA axis function is generally prompt and complete upon discontinuation of short-term or topical corticosteroid therapy. Cushing's syndrome and adrenal suppression may also occur after very frequent use of ophthalmic prednisolone, particularly in very young children. Signs of peritoneal irritation following GI perforation in patients receiving corticosteroids may be minimal or absent. Corticosteroids should not be used in patients where there is a possibility of impending GI perforation, abscess, or pyogenic infection.
7.5 to 60 mg/day PO administered once daily in the morning or every other day as needed for symptom control; alternate day therapy may produce less adrenal suppression. In pediatric patients, the use of oral corticosteroids is usually limited to a few weeks until asthma control is improved and the patient can be stabilized on other, preferred treatments. Blood pressure, body weight, routine laboratory studies, including two-hour postprandial blood glucose and serum potassium, and a chest X-ray should be obtained at regular intervals during prolonged therapy. Upper Gl X-rays are desirable in patients with known or suspected peptic ulcer disease.
Initially 5-60 mg daily in divided doses, as single or double dose on alternate days depending on disease. The onset and duration of action of prednisolone acetate and sodium phosphate suspensions are dependent on the extent of the local blood supply. As glucocorticoids can produce or aggravate Cushing's syndrome, glucocorticoids should be avoided in patients with Cushing's disease unless when needed to correct hypocortisolism that may occur during use of treatments for the condition. 40 mg PO once daily for 5 days is the most commonly recommended regimen.
Also used to replace steroids in conditions of adrenal insufficiency . Prelone is a trade name for the generic drug name Prednisolone. Delta-Cortef, Orapred, and Pediapred are other trade names for Prednisolone. In some cases, health care professionals may use the trade names Prelone, Delta-Cortef, Orapred, and Pediapredwhen referring to the generic drug name Prednisolone.
To help prevent withdrawal, your doctor may lower your dose slowly. Withdrawal is more likely if you have used prednisolone for a long time or in high doses. Tell your doctor or pharmacist right away if you have withdrawal. The dosage and length of treatment are based on your medical condition and response to treatment. Your doctor may direct you to take prednisolone 1 to 4 times a day or take a single dose every other day. Patients who are on immunosuppressant doses of corticosteroids should be warned to avoid exposure to chickenpox or measles.
Acute adrenal insufficiency and even death may occur following abrupt discontinuation of systemic therapy. In addition, a withdrawal syndrome unrelated to adrenocortical insufficiency may occur following sudden discontinuation of corticosteroid therapy. These effects are thought to be due to the sudden change in glucocorticoid concentration rather than to low corticosteroid levels. Withdraw prolonged systemic corticosteroid therapy gradually. HPA suppression can last for up to 12 months following cessation of systemic chronic therapy.
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